Online Reports
COVID-19 IgG Antibody Test
Note: COVID-19 IgG Antibody Test SHOULD NOT BE USED to diagnose Covid-19
According to ICMR Advisory Dated 23-June-2020:"IgG antibodies generally start appearing after two weeks of onset of infection, once the individual has recovered after infection and last for several months. Therefore, the IgG test is not useful for detecting acute infection. However, detection of IgG antibodies for SARS-CoV-2 may be useful in the following situations:
- Serosurveys to understand the proportion of population exposed to infection with SARS-CoV-2 including asymptomatic individuals. Depending upon the level of seroprevalence of infection, appropriate public health interventions can be planned and implemented for prevention and control of the disease. Periodic serosurveys are useful to guide the policy makers.
- Survey in high risk or vulnerable populations (health care workers, frontline workers, immunocompromised individuals, individuals in containment zones etc) to know who has been infected in the past and has now recovered."
What is the COVID-19 IgG Antibody test?
The Covid-19 IgG Antibody test is intended for use as an aid in identifying individuals with an adaptive immune response to SARS-CoV-2, indicating recent or prior infection. The Anti-SARS-CoV-2 IgG test should not be used to diagnose acute SARS-CoV-2 infection. Results are for the detection of SARS-CoV-2 IgG antibodies.
How much does the COVID-19 IgG Antibody Test cost?
Focusing on affordability, we at HOD have made a conscientious effort to price the test as cost-effectively as possible. The test can be conducted by visiting any HOD Center or any HOD Blood Test Centre (BTC) or by booking a Home Collection. Please fill in your details in the request call section below to enable our Customer Care Team to call and assist you with availability. Please note that for home collection, additional collection charges may apply. *T&C apply.
Price*
₹470
- Anti-SARS-CoV-2-IgG IgG Antibody Test
What do the Covid-19 IgG Test Results mean?
Please find a suggestive test interpretation for the results, as suggested by Ortho Clinical Diagnostics.Reactive Result:
- A Reactive test result indicates that IgG antibodies to SARS-CoV-2 were detected, and you are likely to have or previously had COVID-19 and that you have developed an antibody response to the virus
- The referring doctor/healthcare provider will work with you to determine how best to care for you based on the test results along with other factors of your medical history, including any previous symptoms, possible exposure to COVID-19, and the location of places you have recently traveled.
- A Non-Reactive test result means that the IgG antibodies to the virus that causes COVID-19 were not found in your sample.
- However, it is possible for this test to give a Non-Reactive result that is incorrect (false Non-Reactive) in some people with COVID-19 infection. A False Non-Reactive result may occur if you are tested early in your illness and your body hasn’t had time to produce IgG antibodies to infection. This means that you could possibly still have COVID-19 even though the test is Non-Reactive. If this is the case, your doctor/healthcare provider will consider the test result together with all other aspects of your medical history (such as symptoms, possible exposures, and geographical location of places you have recently traveled) in deciding how to care for you.
- It is important that you work with your doctor/healthcare provider to help you understand the next steps you should take.
What do the results indicate?
According to a US EAP Covid-19 Plasma Consortium Study, the following additional information is made available, by the manufacturer Ortho Clinical Diagnostics:| VITROS Anti-SARS-COV2-IgG S/Co | Sero Survey Interpretation* |
|---|---|
| 1-0 – 4.62 | Low Level of Protective Antibodies |
| 4.62 – 18.45 | Medium Level of Protective Antibodies |
| >18.45 | High Level of Protective Antibodies |
Patient S/Co | Nab (Neutralizing Antibody) Titer | % of persons with Nab | Patient S/Co | Nab (Neutralizing Antibody) Titer | % of persons with Nab |
1 - 5 | > 1:80 | 99.40% | 1 - 5 | > 1:80 | 99.40% |
5 - 10 | > 1:160 | 97.70% | 5 - 10 | > 1:80 | 99.90% |
10 - 15 | > 1:320 | 97.20% | 10 - 15 | > 1:80 | 100.00% |
15 - 20 | > 1:640 | 94.60% | 15 - 20 | > 1:80 | 100.00% |
How is the Covid-19 IgG Test Performed?
Please note that the Covid-19 IgG Antibody Test is a blood test and not a swab test. At House Of Diagnostics we are performing Anti-SARS-Cov2-IgG, using C.L.I.A. (Chemi-Luminescence Immuno Assay) Testing on our multiple high-throughput VITROS 5600 Systems, manufactured by Ortho Clinical Diagnostics. The Reagent kits we use known as VITROS Anti-SARS-CoV-2 IgG are US FDA EUA Approved US FDA EUA Authorization and are being used in several countries globally.According to the manufacturer Ortho Clinical Diagnostics, "Experts believe that the Positive Predictive Value (PPV) is the most important metric of accuracy for COVID-19 antibody tests based on the current utilities. PPV is the probability that the test accurately detects the antibodies to COVID-19 and is dependent on the prevalence of the disease. High specificity tests provide a high PPV. Specificities closer to 100% yield high PPV in low or high prevalence areas—so are ideal as prevalence changes. The VITROS® Immunodiagnostic Products Anti-SARS-CoV-2 IgG assay has a specificity of 100%* "
For your interest, please find an interesting video regarding a study on the performance of the test on the VITROS Platform below.
How long do the reports take?
As of July-2020, House Of Diagnostics (HOD) has commenced offering the VITROS Anti-SARS-Cov-2-IgG Tests, on multiple high throughput VITROS 5600 Systems. Our two systems combined can yield several hundred test results per hour, enabling us to deliver the test results within the Same Day if samples are collected before 2PM and the relevant documentation is completed.Who should get the test done on priority?
According to ICMR Advisory Dated 23-June-2020The IgG Test should be prioritized for the following groups of individuals:
Immuno-compromised patients
PLHIV, patients on immuno-suppressive treatment, TB, SARI, COPD, patients on dialysis to be considered for testing
Individuals in containment zones
In identified containment zones and buffer zones where large number/ cluster of cases have been identified as demarcated geographical areas with residential, commercial structures
Health Care Workers
Specifically, all doctors including specialists, nursing staff, support staff, sanitary and other staff including the staff at registration, pharmacists, client facing desk clerks etc. Those workers in health care settings who either faces patients (whether known COVID 19 +ve or not), involved in their care or are in environment of potentially shared spaces or handling fomites
Security personnel
All security personnel facing the visitors, conducting their security screening, physical checking and thermal screening. This includes CISF personnel involved in security especially of offices.
Police and paramilitary personnel civil defense & volunteers
Police personnel and volunteers involved in duties facing large number of individuals or those coming in contact with potentially infected individuals, fomites or settings/ places
Press corps
Press reporters covering field, interviews, press briefings, etc. and support staff
Rural, tribal population (after reverse migration)
Migrant workers who have travelled back from urban and peri-urban areas to rural, tribal, hard to reach areas in the country as well as natives after coming in contact with returned migrants.
Industrial workers or labour force
Industry workers, daily wagers, migrant workers, temporary travel related workers, hospitality related works, service sector who are in large number or groups and has potential to spread transmission rapidly in workplace settings.
Farmers, vendors visiting large markets
Farmers, sellers, brokers, purchasing vendors, distributors and other persons including drivers and labor by virtue of visiting crowded places like main markets where large exchange of materials happen between farmers and vendors during purchase and sell of vegetables etc.
Staff in municipal bodies
Municipal staff working in areas like sanitation, water supply, electricity, etc. where interactions with citizens is expected.
Drivers
Drivers of hospital ambulances, hearse, buses, auto, taxies, etc. who have been on work font faced large number of individual previously or going to face in future. Bus conductors, cleaners and helping staff also should be included
Banks, post, couriers, telecom offices
Public or private banks, small or large branches of banks and post, telecom offices as well as couriers.
Shops
Vendors and/ or owners as well as staff working in shops for essential goods, groceries, vegetables, milk, bread, chemists working at pharmacies, eateries and take away restaurants, etc.
Air travel related staff
All ground staff, security staff, janitors, sanitation staff, flight captains and crew for domestic and international as well as cargo may be considered.
International operations
All members of overseas operations for evaluation
Congregate settings
People staying or working in slums with very high population density with poorly ventilated building, structures. Persons staying in institutional settings like old age homes, orphanage, asylums, shelters for homeless, hostels, etc. may also be considered.
Prisons
All prisoners with or without symptoms whenever there is a batch transfer or reported symptomatic.